1. Adipose tissue’s nutrient utilization and its roles in systemic metabolic homeostasis.
2. Mechanisms by which nutrient sensing pathways regulate metabolism.
3. Crosstalk between signaling and metabolism.
Education
2009-2014: Ph.D., Department of Biological Sciences, Sungkyunkwan University (SKKU), Korea
2005-2009: B.S., Department of Biological Sciences, Sungkyunkwan University (SKKU), Korea
Experience
2016-2021: Postdoctoral Associate, University of Massachusetts Medical School, MA, U.S.
2015-2016: Postdoctoral Associate, University of Texas MD Anderson Cancer Center, TX, U.S.
2014-2015: Postdoctoral Fellow, Sungkyunkwan University (SKKU), Korea
Journal Articles
(2023)
N-Hydroxy-Phe-Phe, a new dipeptide, and cytotoxic macrocyclic trichothecenes from the lethal toxic mushroom Podostroma cornu-damae.
ORGANIC & BIOMOLECULAR CHEMISTRY.
21,
42
(2023)
Arteriovenous Metabolomics to Measure In Vivo Metabolite Exchange in Brown Adipose Tissue.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.
2023,
200
(2023)
Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling.
NUTRIENTS.
15,
16
(2023)
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis.
NATURE METABOLISM.
5,
7
(2023)
Peli3 ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3β phosphorylation and mitochondrial translocation.
EXPERIMENTAL AND MOLECULAR MEDICINE.
55,
6
(2022)
Structural mechanism for regulation of Rab7 by site-specific monoubiquitination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.
194,
.
(2021)
In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate.
CELL REPORTS.
36,
4
(2020)
The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development.
CELL REPORTS.
33,
1
(2020)
mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis.
NATURE COMMUNICATIONS.
11,
1
(2019)
The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway.
EBIOMEDICINE.
49,
-
(2019)
Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1.
MOLECULAR CELL.
75,
4
(2019)
Brown fat organogenesis and maintenance requires AKT1 and AKT2.
MOLECULAR METABOLISM.
23,
-
(2019)
A Reciprocal Role of the Smad4-Taz Axis in Osteogenesis and Adipogenesis of Mesenchymal Stem Cells.
STEM CELLS.
37,
3
(2019)
Brown adipose tissue development and metabolism.
Handbook of Experimental Pharmacology.
251,
-
(2018)
Insulin PACS a Punch in SIRT1 Activity.
MOLECULAR CELL.
72,
6
(2018)
The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation.
EMBO REPORTS.
19,
4
(2017)
A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1.
NATURE CELL BIOLOGY.
19,
10
(2017)
The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond.
TRENDS IN ENDOCRINOLOGY AND METABOLISM.
28,
5
(2017)
The deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein.
FEBS LETTERS.
591,
3
(2015)
Inhibition of lethal inflammatory responses through the targeting of membrane-associated Toll-like receptor 4 signaling complexes with a Smad6-derived peptide.
EMBO MOLECULAR MEDICINE.
7,
-
Publications
(2022)
Brown Adipose Tissue, Methods and Protocols.
Methods in Molecular Biology.
Lead author
Honors / Awards
2018-2020: American Diabetes Association (ADA) Postdoctoral Fellowship (#1-18-PDF-128)
2014: Excellent Doctoral Thesis Award, The International Conference of the Korean Society for Molecular and Cellular Biology (KSMCB)
2009-2011: Lotte Natural Science and Engineering Scholarship, Lotte Scholarship Foundation
